Abstract: Morphological changes of optic nerve in pathological myopia include retinal nerve fiber layer thinning or defect, optic disc alterations, which may contribute to functional abnormality . Structural and functional changes can also occur due to posterior staphyloma and biomechanical differences. Some morphological changes are related to glaucoma contribution, however others should affect to be differentiated from glaucoma. (Int Rev Ophthalmol, 2014, 38: 189-193)